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OPTOGENETICS AND CHEMOGENETICSUsing optogenetics and chemogenetics we are able to control the activity of targeted subpopulation of neurons in mice while they are performing behavioural tasks. Thanks to these techniques, we can causally link the contribution of specific cells in particular cognitive functions.
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IN VIVO CALCIUM IMAGINGWe use miniaturized microscopes implanted in the mouse brain, to visualize the neuronal activity in real time while the mice are performing behavioural tasks.
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NETWORK ANALYSISSpecific cognitive functions are thought to be supported by the coordinated activity of a distributed network of brain regions, rather than isolated brain regions alone. We use a network approach to explore regions that are co-active during the recall of memory traces in normal and pathological conditions.
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BEHAVIOURThe behavioural analysis is a key component of our research: the final goal is to understand the mice behaviour during the processing of learning and memory tasks by decoding their neuronal activity and brain plasticity.
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